EPI Suite

Estimation Program Interface (EPI) Suite is a collection of several modules for the prediction of physicochemical and environmental fate endpoints developed by the Environmental Protection Agency (EPA) and by the Syracuse Research Corporation (SRC).

EPISuite predictions are not supported by a specific parameter for the assessment of their reliability and models applicability domain.

However, it is generally assumed that property estimates are less accurate for compounds outside the molecular weight (MW) range of the training set compounds, and/or compounds that have more instances of a given fragment than the maximum for all training set compounds, and/or compounds that have a functional group(s) or other structural features not represented in the training set.